What is russel body?

Russell bodies are abnormal, spherical, eosinophilic intracellular inclusions found in certain types of plasma cells. They were first described by Dr. Alexander Russell in 1890.

Russell bodies can be associated with a variety of conditions including multiple myeloma, Waldenstrom macroglobulinemia, chronic lymphocytic leukemia, and autoimmune diseases such as rheumatoid arthritis.

The presence of Russell bodies in plasma cells can indicate a high level of antibody production, but it can also be a sign of plasma cell dysfunction.

While Russell bodies may not be harmful in themselves, their presence can indicate underlying disease and may have implications for diagnosis, prognosis, and treatment.